A fresh leaf is split and its gel applied directly to the affected skin area in a thin layer. This topical application has traditionally been reserved for short durations. Dosage must be validated with a healthcare professional or recognized pharmacopoeia before use.
A small piece of leaf was sometimes boiled and then abundantly diluted before consumption, according to reported folk uses. This preparation requires extreme caution and the advice of a qualified professional due to the plant's irritating compounds. Dosage must be validated with a healthcare professional or recognized pharmacopoeia before use.
Agave americana is now found cultivated outdoors in regions with mild, dry climates, particularly in the Mediterranean zone, often as an ornamental plant. Agave sap or preparations are less commonly found in specialized herbal shops, as the plant is better known for its horticultural and artisanal uses than therapeutic ones.
Leaves are traditionally harvested year-round from mature plants, preferably outside of frost periods.